🧪 FXE

🧪 FXE (Fluorexetamine – 2-(ethylamino)-2-(3′-fluorophenyl)cyclohexanone)

Forensic and Analytical Overview

1. Chemical Identification

Common name: FXE
Systematic name: 2-(ethylamino)-2-(3′-fluorophenyl)cyclohexanone
Chemical class: Arylcyclohexylamine
Molecular formula: C₁₄H₂₀FNO
Molecular weight: ~237.31 g/mol
Structural relation: Fluorinated analogue of methoxetamine (MXE) and structurally related to ketamine and other dissociative arylcyclohexylamines.

2. Background

Fluorexetamine (FXE) is a synthetic dissociative compound from the arylcyclohexylamine family, first identified in the mid-2010s.
Developed as part of ongoing chemical exploration into NMDA receptor antagonists, FXE is closely related to MXE and ketamine analogues, differing primarily by the substitution of a fluorine atom on the aromatic ring.

Its appearance in forensic and toxicological literature has focused on analytical differentiation, receptor interaction mapping, and the development of detection methods for novel dissociative substances.

3. Analytical Characterization

Common analytical techniques used for FXE include:

• Gas Chromatography–Mass Spectrometry (GC–MS)

• Liquid Chromatography–Mass Spectrometry (LC–MS)

• Infrared (IR) Spectroscopy

• Nuclear Magnetic Resonance (NMR) Spectroscopy

• High-Resolution Mass Spectrometry (HRMS)

Distinctive fluorine isotope patterns and specific fragmentation peaks aid in differentiating FXE from similar arylcyclohexylamines such as MXE, ketamine, and 3-MeO-PCE.

4. Research and Forensic Relevance

FXE is primarily used in:

• Analytical and forensic identification studies

• Structural comparison of arylcyclohexylamine analogues

• Toxicological metabolism and screening research

• Development of reference standards for laboratory and regulatory applications

5. Legal and Safety Notes

Status: Controlled or restricted in various jurisdictions under analogue or NPS laws.
Handling: Limited to authorized laboratories holding appropriate research licenses.
Storage: Store in sealed containers away from heat, light, and moisture.
Safety: Laboratory staff should utilize PPE and follow institutional chemical handling procedures at all times.

6. Summary

FXE (Fluorexetamine) is a fluorinated arylcyclohexylamine analogue used exclusively in analytical, forensic, and pharmacological research.
Its defined molecular structure and distinct analytical signature make it a key reference point in the study of dissociative compounds within the NMDA antagonist class.

⚠️ For Research Use Only / Not for Human Consumption
Not for medical, veterinary, or household use.
For qualified laboratory professionals only.