🧪 2F-DCK

🧪 2F-DCK (2-Fluorodeschloroketamine – 2-(2-fluorophenyl)-2-(methylamino)-cyclohexanone)

Forensic and Analytical Overview

1. Chemical Identification

Common name: 2F-DCK
Systematic name: 2-(2-Fluorophenyl)-2-(methylamino)-cyclohexanone
Chemical class: Arylcyclohexylamine
Molecular formula: C₁₃H₁₆FNO
Molecular weight: ~221.27 g/mol
Structural relation: Fluorinated analogue of deschloroketamine (DCK) and closely related to ketamine and other dissociative NMDA receptor antagonists.

2. Background

2F-DCK, or 2-Fluorodeschloroketamine, is a dissociative compound within the arylcyclohexylamine class that emerged in analytical and forensic literature in the mid-2010s.
It is structurally related to ketamine but lacks the chlorine substitution, replaced with a fluorine atom, resulting in distinctive analytical and pharmacological properties.

The compound has been primarily used in toxicological and forensic investigations focused on differentiating ketamine analogues and understanding their receptor activity profiles.

3. Analytical Characterization

Standard laboratory techniques employed for 2F-DCK identification include:

• Gas Chromatography–Mass Spectrometry (GC–MS)

• Liquid Chromatography–Mass Spectrometry (LC–MS)

• Infrared (IR) Spectroscopy

• Nuclear Magnetic Resonance (NMR) Spectroscopy

• High-Resolution Mass Spectrometry (HRMS)

Characteristic fluorine isotopic patterns and fragmentation pathways allow for reliable analytical identification and differentiation from ketamine, DCK, and related analogues.

4. Research and Forensic Relevance

2F-DCK is used for:

• Analytical and forensic identification in seized material testing

• Comparative studies of arylcyclohexylamine analogues

• Pharmacological and receptor interaction research

• Development of analytical reference standards for laboratory use

5. Legal and Safety Notes

Status: Controlled or restricted in several jurisdictions under analogue or NPS legislation.
Handling: Authorized laboratory research only; licensing required.
Storage: Store in sealed containers away from moisture and direct light.
Safety: Laboratory personnel must use appropriate PPE and adhere to approved safety and disposal procedures.

6. Summary

2F-DCK is a fluorinated analogue of deschloroketamine utilized exclusively for analytical, forensic, and pharmacological research.
Its defined structure and unique mass spectral profile make it a valuable compound for NMDA antagonist studies and analytical reference development.

⚠️ For Research Use Only / Not for Human Consumption
Not for medical, veterinary, or household use.
For qualified laboratory professionals only.