🧪 MDPHP

🧪 MDPHP (3′,4′-Methylenedioxy-α-pyrrolidinohexanophenone)

Forensic and Analytical Overview

1. Chemical Identification

Common name: MDPHP
Systematic name: 1-(3,4-Methylenedioxyphenyl)-2-(pyrrolidin-1-yl)hexan-1-one
Chemical class: Pyrrolidinophenone / Synthetic cathinone
Molecular formula: C₁₇H₂₃NO₃
Molecular weight: ~289.37 g/mol
Structural relation: Methylenedioxy-substituted analogue of α-PHP and structurally related to MDPV (3,4-Methylenedioxypyrovalerone).

2. Background

MDPHP (3′,4′-Methylenedioxy-α-pyrrolidinohexanophenone) is a synthetic stimulant belonging to the pyrrolidinophenone subclass of cathinones.
It emerged in forensic literature during the mid-2010s as an analogue of MDPV and A-PHP, distinguished by its methylenedioxyphenyl ring substitution, a motif also found in compounds of pharmacological and toxicological interest.

While it shares structural features with known dopaminergic stimulants, MDPHP has no recognized therapeutic or veterinary applications and is restricted to controlled laboratory environments for analytical and forensic research only.

3. Analytical Characterization

Identification and confirmation are achieved via:

• Gas Chromatography–Mass Spectrometry (GC–MS)

• Liquid Chromatography–Mass Spectrometry (LC–MS)

• Infrared (IR) and Raman Spectroscopy

• Nuclear Magnetic Resonance (NMR)

• High-Resolution Mass Spectrometry (HRMS)

Key analytical features include diagnostic fragments associated with pyrrolidine ring cleavage and the methylenedioxy group, with distinctive β-ketone ion peaks in the 100–150 m/z range.

4. Research and Forensic Relevance

MDPHP is primarily utilized for:

• Analytical and forensic profiling of substituted cathinones

• Comparative spectral analysis within the α-PHP / MDPV family

• Toxicological screening method development

• Establishment of retention and fragmentation reference data

5. Legal and Safety Notes

Status: Controlled or listed as an NPS under analogue and stimulant legislation in many regions.
Handling: For qualified researchers in accredited laboratories only.
Storage: Keep sealed, dry, and protected from heat or light exposure.
Safety: Employ standard laboratory PPE and follow institutional safety guidelines.

6. Summary

MDPHP is a methylenedioxy-substituted pyrrolidinophenone investigated primarily for its analytical and forensic relevance.
Its examination supports ongoing research into synthetic cathinone identification and classification.

⚠️ For Research Use Only / Not for Human Consumption
Not intended for medical, veterinary, or household use.
For laboratory and analytical research purposes only.