🧪 A-PHP

🧪 A-PHP (α-Pyrrolidinohexanophenone)

Forensic and Analytical Overview

1. Chemical Identification

Common name: A-PHP
Systematic name: 1-Phenyl-2-(pyrrolidin-1-yl)-pentan-1-one
Chemical class: Pyrrolidinophenone / Synthetic cathinone
Molecular formula: C₁₆H₂₃NO
Molecular weight: ~245.36 g/mol
Structural relation: Homologue of α-PVP, featuring a hexanone backbone with a pyrrolidine ring substitution.

2. Background

A-PHP (α-Pyrrolidinohexanophenone) is a synthetic stimulant compound from the pyrrolidinophenone class, closely related to α-PVP and A-PiHP.
It first appeared in analytical and toxicological literature around the early-to-mid 2010s, where it was reported in forensic casework and analytical monitoring of cathinone-type stimulants.

Its molecular framework provides a useful reference for studying dopaminergic and noradrenergic transporter interactions, making it of continued interest in forensic and pharmacological research.
A-PHP is not approved for human or veterinary use and is restricted to laboratory research applications.

3. Analytical Characterization

Analytical methods for detection and confirmation include:

• Gas Chromatography–Mass Spectrometry (GC–MS)

• Liquid Chromatography–Mass Spectrometry (LC–MS)

• Infrared (IR) and Raman Spectroscopy

• Nuclear Magnetic Resonance (NMR)

• High-Resolution Mass Spectrometry (HRMS)

Characteristic analytical markers include fragmentation patterns featuring pyrrolidine cleavage and β-keto ion peaks, consistent with other α-pyrrolidinophenone derivatives.

4. Research and Forensic Relevance

A-PHP is primarily utilized for:

• Analytical and forensic identification of pyrrolidinophenones

• Comparative analysis within the α-PVP analogue series

• Spectral reference and retention index database development

• Toxicological screening and compound differentiation

5. Legal and Safety Notes

Status: Controlled or restricted under analogue and NPS legislation in multiple regions.
Handling: For authorized laboratories and qualified personnel only.
Storage: Store sealed, in cool and dry conditions, away from light and humidity.
Safety: Employ appropriate PPE and follow all institutional chemical safety protocols.

6. Summary

A-PHP (α-Pyrrolidinohexanophenone) is a forensically significant synthetic cathinone studied for its analytical properties and similarity to α-PVP.
It remains a reference point in laboratory research focusing on emerging stimulant analogues.

⚠️ For Research Use Only / Not for Human Consumption
Not intended for medical, veterinary, or household use.
Authorized research and analytical purposes only.