🧪 A-PiHP

🧪 A-PiHP (α-Pyrrolidinoisohexanophenone)

Forensic and Analytical Overview

1. Chemical Identification

Common name: A-PiHP
Systematic name: 1-Phenyl-2-(pyrrolidin-1-yl)-hexan-1-one
Chemical class: Pyrrolidinophenone / Cathinone analogue
Molecular formula: C₁₆H₂₅NO
Molecular weight: ~247.38 g/mol
Structural relation: Structural analogue of α-PVP and α-PHP, featuring a hexyl side chain and a pyrrolidinyl substitution on the nitrogen atom.

2. Background

A-PiHP is a synthetic stimulant compound belonging to the cathinone and pyrrolidinophenone family.
First described in forensic and toxicological literature in the mid-2010s, it gained attention as part of the broader group of α-PVP analogues studied for their stimulant and dopaminergic properties.

While sharing chemical similarities with known central nervous system stimulants, A-PiHP is not intended for medical or veterinary use. It has been detected in analytical casework and laboratory profiling of novel psychoactive substances (NPS).

3. Analytical Characterization

Laboratory identification is typically performed using:

• Gas Chromatography–Mass Spectrometry (GC–MS)

• Liquid Chromatography–Mass Spectrometry (LC–MS)

• Infrared (IR) and Raman Spectroscopy

• Nuclear Magnetic Resonance (NMR)

• High-Resolution Mass Spectrometry (HRMS)

Characteristic analytical data include β-keto fragmentation patterns, prominent m/z fragments associated with pyrrolidine cleavage, and retention indices consistent with other α-pyrrolidinophenone derivatives.

4. Research and Forensic Relevance

A-PiHP is utilized for:

• Analytical and forensic identification of cathinone analogues

• Development of spectral and chromatographic reference standards

• Toxicological screening and compound differentiation

• Comparative structure–activity research within the α-PVP family

5. Legal and Safety Notes

Status: Controlled or listed under analogue legislation in many jurisdictions.
Handling: Restricted to qualified personnel within accredited laboratory environments.
Storage: Keep sealed in a dry, temperature-controlled environment.
Safety: Follow local laboratory safety regulations and use appropriate protective equipment.

6. Summary

A-PiHP (α-Pyrrolidinoisohexanophenone) is a pyrrolidinophenone-class stimulant analogue investigated primarily for forensic and analytical research.
Its inclusion in laboratory reference databases supports ongoing efforts to monitor and identify synthetic cathinone derivatives.

⚠️ For Research Use Only / Not for Human Consumption
Not intended for medical, veterinary, or household use.
For qualified laboratory and analytical applications only.