🧪 MDPiHP

🧪 MDPHiP (3′,4′-Methylenedioxy-α-pyrrolidinoisohexanophenone)

Forensic and Analytical Overview

1. Chemical Identification

Common name: MDPHiP
Systematic name: 1-(3,4-Methylenedioxyphenyl)-2-(pyrrolidin-1-yl)-hexan-1-one
Chemical class: Pyrrolidinophenone / Synthetic cathinone
Molecular formula: C₁₇H₂₃NO₃
Molecular weight: ~289.37 g/mol
Structural relation: Methylenedioxy analogue of A-PiHP; closely related to MDPHP and MDPV, with a hexyl side chain extension and pyrrolidine ring substitution.

2. Background

MDPHiP is a synthetic stimulant of the pyrrolidinophenone family, first reported in forensic literature during the late 2010s.
It represents the methylenedioxy variant of A-PiHP, combining the structural motifs of A-PHP analogues with a 3,4-methylenedioxyphenyl ring, a feature often studied for its role in monoaminergic system interactions.

While its structure is comparable to other known dopaminergic agents, MDPHiP is not approved for medical or veterinary use and is strictly employed in laboratory research to study analytical, forensic, and toxicological properties of synthetic cathinones.

3. Analytical Characterization

Identification methods include:

• Gas Chromatography–Mass Spectrometry (GC–MS)

• Liquid Chromatography–Mass Spectrometry (LC–MS)

• Infrared (IR) and Raman Spectroscopy

• Nuclear Magnetic Resonance (NMR)

• High-Resolution Mass Spectrometry (HRMS)

Typical GC–MS fragmentation displays prominent ions corresponding to β-keto cleavage and pyrrolidine detachment, with the methylenedioxy fragment (m/z = 135) serving as a key diagnostic indicator.

4. Research and Forensic Relevance

MDPHiP is primarily studied for:

• Analytical and forensic identification of cathinone analogues

• Comparative spectral evaluation with MDPHP and MDPV

• Toxicological detection and metabolite mapping

• Reference data generation for forensic databases and chemical libraries

5. Legal and Safety Notes

Status: Controlled or listed under analogue/stimulant legislation in multiple jurisdictions.
Handling: Restricted to qualified researchers within certified laboratories.
Storage: Keep in sealed containers, away from direct light and humidity.
Safety: Observe appropriate PPE use and institutional chemical handling protocols.

6. Summary

MDPHiP (3′,4′-Methylenedioxy-α-pyrrolidinoisohexanophenone) is a forensically relevant pyrrolidinophenone analogue used exclusively for analytical and toxicological research.
Its identification contributes to the expanding body of data on emerging synthetic cathinones and their structural variants.

⚠️ For Research Use Only / Not for Human Consumption
Not intended for medical, veterinary, or household use.
For qualified laboratory research applications only.