1P-LSD 100mcg Blotters or 1-propionyl-lysergic acid diethylamide blotters are a psychedelic of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52.

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1P-LSD is a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group. 1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound. Learn more

1P-LSD 100mcg Blotters Pharmacology
Based on its structural similarity to LSD, 1P-LSD 100mcg Blotters likely act as a partial agonist at the 5-HT2A receptor. The effects are thought to primarily come from its efficacy at the 5-HT2A receptors. 1P-LSD 100mcg Blotters also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine.

It has been theorized that 1P-LSD may act as a prodrug for LSD. LSD is detected via LC-MS when 1P-LSD is incubated in human serum. Follow-up studies are currently being conducted to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, and to determine whether 1P-LSD is hydrolyzed to LSD in vivo. Otherwise, it is possible that 1P-LSD may be capable of exerting its own psychedelic effect.

Subjective effects
Anecdotal reports from many users suggest that the subjective effects of 1P-LSD are so similar to that of LSD so as to be virtually indistinguishable from one another. In comparison to other psychedelics such as psilocybin, LSA, and ayahuasca, 1P-LSD 100mcg Blotters are significantly more stimulating and fast-paced regarding the specific style of its physical and cognitive effects